281 CONFERENCE
- Highmore-Harrold Pirates
- Hitchcock-Tulare Patriots
- Iroquois/Doland Chiefs
- James Valley Christian Vikings
- Sanborn Central/Woonsocket Blackhawks
- Sunshine Bible Academy Crusaders
- Wessington Springs Spartans
- Wolsey-Wessington Warbirds
BIG EAST CONFERENCE
- Baltic Bulldogs
- Beresford Watchdogs
- Chester Area Flyers
- Flandreau Fliers
- Garretson Blue Dragons
- McCook Central/Montrose Fighting Cougars
- Parker Pheasants
- Sioux Valley Cossacks
BLACK HILLS CONFERENCE
- Belle Fourche Broncs
- Custer Wildcats
- Douglas Patriots
- Hill City Rangers
- Hot Springs Bison
- Lead-Deadwood Golddiggers
- RC Christian Comets
- Red Cloud Crusaders
- Sturgis Scoopers
- Spearfish Spartans
- St. Thomas More Cavaliers
CENTRAL SOUTH DAKOTA CONFERENCE
- Faulkton Area Trojans
- Highmore-Harrold Pirates
- Miller Rustlers
- Mobridge-Pollock Tigers
- Potter County Battlers
- Sully Buttes Chargers
- Sunshine Bible Academy Crusaders
- Wolsey-Wessington Warbirds
CORNBELT CONFERENCE
- Bridgewater-Emery Huskies
- Canistota Hawks
- Freeman Flyers
- Hanson Beavers
- Howard Tigers
- Irene-Wakonda Eagles
- Menno Wolves
- Viborg-Hurley Cougars
DAKOTA XII CONFERENCE
- Canton C-Hawks
- Dakota Valley Panthers
- Dell Rapids Quarriers
- Elk Point-Jefferson Huskies
- Lennox Orioles
- Madison Bulldogs
- Sioux Falls Christian Chargers
- Tea Area Titans
- Tri-Valley Mustangs
- Vermillion Tanagers
- West Central Trojans
DAKOTA VALLEY CONFERENCE
- Arlington Cardinals
- Castlewood Warriors
- Colman-Egan Hawks
- De Smet Bulldogs
- Deubrook Area Dolphins
- Elkton-Lake Benton Elks
- Estelline/Hendricks Redhawks
- Lake Preston Divers
- Oldham-Ramona/Rutland Raiders
- St. Mary Cardinals
EASTERN COTEAU CONFERENCE
- Dakota Hills Grizzlies (Football, T&F Co-Op)
- Florence/Henry Falcons
- Great Plains Lutheran Panthers
- Tri-State Tigers
- Waverly-South Shore Coyotes
- Waubay-Summit Mustangs
- Wilmot Wolves
ESD CONFERENCE
- Aberdeen Central Golden Eagles
- Brandon Valley Lynx
- Brookings Bobcats
- Harrisburg Tigers
- Huron Tigers
- Mitchell Kernels
- Pierre Governors
- Watertown Arrows
- Yankton Bucks
- RC Stevens Raiders (Football Only)
- RC Central Cobblers (Football Only)
GREAT PLAINS CONFERENCE
- Alcester-Hudson Cubs
- Andes Central/Dakota Christian Thunder
- Avon Pirates
- Burke Cougars
- Centerville Tornadoes
- Colome Cowboys
- Corsica-Stickney Jaguars
- Freeman Academy/Marion Bearcats
- Gayville-Volin Raiders
- Marty Braves
- Scotland Highlanders
- Tripp-Delmont/Armour Nighthawks
LAKE CENTRAL CONFERENCE
- Clark-Willow Lake Cyclones
- Castlewood Warriors
- De Smet Bulldogs
- Deuel Cardinals
- Flandreau Fliers
- Hamlin Chargers
- Sioux Valley Cossacks
LAKE REGION CONFERENCE
- Aberdeen Christian Knights
- Frederick Area Titans
- Ipswich Tigers
- Langford Area Lions
- Leola Titans
- North Central Thunder
- Northwestern Wildcats
- Warner Monarchs
LMC Conference
- Bison Cardinals
- Dupree Tigers
- Faith Longhorns
- Harding County Ranchers
- Lemmon Cowboys
- McIntosh Tigers
- Newell Irrigators
- Timber Lake Panthers
METRO CONFERENCE
- Brandon Valley Lynx
- Jefferson Cavaliers
- Harrisburg Tigers
- Lincoln Patriots
- O’Gorman Knights
- Roosevelt Rough Riders
- Washington Warriors
NORTHEAST CONFERENCE
- Aberdeen Roncalli Cavaliers
- Britton-Hecla Braves
- Clark/Willow Lake Cyclones
- Deuel Cardinals
- Groton Area Tigers
- Hamlin Chargers
- Milbank Bulldogs
- Redfield Pheasants
- Sisseton Redmen
- Tiospa Zina Wambdi
- Webster Area Bearcats
SESD CONFERENCE
- Bon Homme Cavaliers
- Chamberlain Cubs
- Ethan Rustlers
- Gregory Gorillas
- Mt.Vernon/Plankinton Titans
- Parkston Trojans
- Platte-Geddes Black Panthers
- Wagner Red Raiders
- Winner Warriors
WESTERN GREAT PLAINS CONFERENCE
- Bennett County Warriors
- Jones County Coyotes
- Kadoka Area Kougars
- Lyman Raiders
- New Underwood Tigers
- Philip Scotties
- Wall Eagles
- White River Tigers
ALL-NATIONS A (FOOTBALL)
- Cheyenne-Eagle Butte Braves
- Flandreau Indian Indians
- Little Wound Mustangs
- Pine Ridge Thorpes
- Red Cloud Crusaders
- St. Francis Indian Warriors
- Todd County Falcons
ALL-NATIONS B (FOOTBALL)
- Crazy Horse Chiefs
- Crow Creek Chieftains
- Lower Brule Sioux
- Marty Braves
- McLaughlin Mustangs
- Oelrichs Tigers
- Takini Skyhawks
- Tiospa Zina Wambdi
NON AFFLIATED/UNKNOWN
Class A
- Stanley County
- Lakota Tech
- Todd County
Class B
- Herreid/Selby Area
- Mitchell Christian
- Sioux Falls Lutheran
- Kimball/White Lake
- Oelrichs
- Wakpala
Centerville is a member of the Great Plains Conference